Wpływ terapii fotodynamicznej (PDT) na biofilm Enterococcus faecalis w pierwotnych i wtórnych zakażeniach doświadczalnych kanału korzeniowego
Photodynamic therapy (PDT), also known as photoradiation therapy, phototherapy, photochemotherapy, or photoactivated chemotherapy (PACT) is a medical treatment, that utilizes the activation of a photosensitizing agent (photosensitizer) by exposure to light of a specific wave length in the presence of oxygen [17]. There is an energy transfer from the activated photosensitizer to available oxygen that results in the formation of toxic oxygen species, such as singlet oxygen and free radicals. Singlet oxygen and radical species cause a rapid and selective destruction of microorganisms. Most photosensitizers are activated by light between 630 and 700 nm. The main photosensitizers found in the literature are hematoporphyrin derivatives (620–650 nm), phenothiazine, like toluidine blue and methylene blue (620–700 nm), cyanine (600–805 nm), phytotherapic agents (550–700 nm) and hytalocyanines (660–700 nm) [18-20].
PDT has been shown to be an adjunctive therapy to conventional endodontic treatment to optimize the microbial reduction in root canals in primary endodontic infections [21-23]. Garcez et al. [24] investigated the effect of PDT in endodontic retreatments in vivo. They found that PDT as an adjuvant to conventional endodontic treatment leads to a significant further reduction of bacterial load after irrigation using sodium hypochlorite, hydrogen peroxide and EDTA and is effective against multi-drug resistant bacteria. In retreatments it is impossible to remove the root canal filling completely, impeding disinfection of the root canal system. Based on previous findings, PDT is supposed to have an additional antimicrobial effect after root canal irrigation, especially on [...]
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