Reakcja ludzkich komórek struktur jamy ustnej na różne materiały endodontyczne – badanie in vitro
Nevertheless, the selection of a repair material is critical because biocompatibility and sealing ability are reported to have an effect on the prognosis of perforation closure or apicoectomy [22]. The biocompatibility of endodontic materials is essential because during application the materials/cements might get direct contact to the surrounding
bone or the periodontium for a prolonged period of time. Periodontal ligament (PDL) fibroblasts with specialized functions are responsible for the formation and maintenance of PDL fibre attachments as well as repair, remodelling, and regeneration of the adjacent alveolar bone and cementum [23]. PDL cells are responsible for normal maintenance and regeneration of the PDL [24]. In addition to PDL fibroblasts, cells from the surrounding alveolar bone are likely to play an important role in the repair and regeneration of periradicular tissue [25]. PDL cells are usually formed around the root-end or perforation filling materials [26]. Osteoblasts and PDL cells are the principal cells responsible for osseous excisional wound healing after periradicular surgery [27].
Thus, the aim of this investigation was to analyze the biological interaction of human osteoblasts, and cells of the PDL with different endodontic restorative materials: Mineral Trioxide Aggregate cement (ProRoot MTA), Biodentine (as another calcium silicate cement), amalgam, and composite resin up to 20 days in vitro. Amalgam and composite were included in the study design to analyze their biological effects on cells in direct proximity to further clarify their influence on cell proliferation in an in vitro setting.
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