Reakcja ludzkich komórek struktur jamy ustnej na różne materiały endodontyczne – badanie in vitro
Thus, in vivo amalgam used as material to repair furcation perforations leads to severe inflammatory response in the furcal bone [43]. In contact to PDL cells amalgam showed a mild [44] to severe [45] cytotoxicity showing early manifestation of cell injury [25]. Thus, Zhu et al. found a significantly lower total cell number of osteoblasts and PDL cells in direct contact to amalgam compared to the untreated control group after 3 d and 7 d [46].
Compared to MTA in direct contact to human PDL cells amalgam was significantly more cytotoxic within 1 d and the PDL cell density was lower after 4 d [47, 48]. After 72 h direct contact to amalgam the number of osteoblast-like cells was significantly lower than after contact to MTA. Whereas the number of the cells in the MTA group was significantly lower than that in the untreated control group [49].
The result of this study showed that the negative impact amalgam on human PDL cells and osteoblasts was not as distinct as hypothesized. Nevertheless, because the quantity of PDL cells and osteoblasts were significantly lower than in the control group at all days, amalgam showed no bioactivity and thus cannot be recommended as filling material in endodontic surgery.
Only limited reports about the influence of composite resins on cells associated with bone formation and periodontal repair are available [50]. Hence, ex vivo [...]
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